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Knowing firsthand the merciless evil he faces, Isaac is more aggressive in his second adventure, focusing not only on his own survival, but also on destroying as many Necromorph monsters as he can along the way. The soul-wrenching malady that devastated the base he was sent to explore in the first game seems somehow to have followed Isaac to his haven in the second adventure, however, and the Sprawl is soon infested with Necromoprhs - hideously mutated creatures, single-mindedly devoted to death and destruction. The game is set on a large, heavily populated space station called the Sprawl, where the hero was taken to recover from the terrors he experienced in the first adventure. In the lonely role of a sole survivor on a deep-space station, players use commandeered firearms and makeshift traps to overcome a relentless onslaught of gruesome mutant space zombies.
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